Cohen SY, Creuzot-Garcher C, Darmon J, Desmettre T, Korobelnik JF, Levrat F, Quentel G, Paliès S, Sanchez A, de Gendre AS, Schluep H, Weber M, Delcourt C.
Centre Ophtalmologique d'Imagerie et de Laser, 11 Rue Antoine Bourdelle, 75015 Paris, France. firstname.lastname@example.org
AIM: To describe the types and location of choroidal neovascularisation
(CNV) in exudative age-related macular degeneration (AMD), including
vascularised pigment epithelial detatchments (PED), and most recently
such as retinal choroidal anasmostosis, also termed "retinal angiomatous
proliferation" (RAP). METHODS: Prospective multicentre consecutive
descriptive case series. A total of 207 consecutive cases of newly diagnosed
exudative AMD undergoing fluorescein angiography (FA) were recruited by
7 French referral hospital-based or private centres. Indocyanine green
angiography (ICG) also was performed, when judged necessary by investigators.
Types and location of CNV were classified by two independent experts and
adjudicated by a third when discordant. RESULTS: All patients had FA, while
ICG was performed in 50% of subjects. A total of 17.6% had classic CNV
only, 5.4% and 8.3% had predominantly and minimally classic CNV, respectively.
Occult CNV could be classified in occult CNV without PED (32.7%) and occult
CNV with PED, ie, vascularised PED (23.9%). RAP was observed in 15.1% of
cases, and accounted for 30% of vascularised PED. In 5.8% of the cases
there was haemorrhagic AMD and 4.8% had fibrovascular scars. Lesions were
mainly subfoveal (80%). Agreement between the centre's ophthalmologist
and the final validated expert classification was moderate (kappa = 0.52
for location and 0.59 for type of lesion). CONCLUSION: This study confirms
that newly diagnosed cases of exudative AMD are mainly occult and subfoveal.
RAP appeared as a common lesion in patients with newly diagnosed exudative